TFRC

Transferinski receptor (p90, CD71)
Transferinski receptor (p90, CD71)
	PDB prikaz baziran na 1cx8.
Dostupne strukture
	1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifikatori
Simboli	TFRC; CD71; T9; TFR; TFR1; TR; TRFR; p90
Vanjski ID	OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC Gene
Ontologija gena
Molekularna funkcija	• aktivnost transferinskog receptora; • aktivnost peptidaze;
Celularna komponenta	• ekstracelularni region; • endozom; • ćelijska membrana; • integralno sa ćelijskom membranom; • kaveola; • membrana;
Biološki proces	• proteoliza; • ćelijska homeostaza jona gvožđa; • interakcija virusa i domaćina;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	7037
Ensembl	ENSG00000072274
UniProt	P02786
RefSeq (mRNA)	NM_001128148.1
RefSeq (protein)	NP_001121620.1
Lokacija (UCSC)	Chr 3:; 195.75 - 195.81 Mb
PubMed pretraga	[1]

Transferinski receptor 1 (TfR1, Klaster diferencijacije 71, CD71) je protein koji je kod ljudi kodiran TFRC genom.^[1]^[2] TfR1 je neohodan za prenos gvožđa vezanog za transferin u ćelije.^[3]^[4]

^ Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (1981). „Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin”. Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515—9. PMC 319822 . PMID 6270680. doi:10.1073/pnas.78.7.4515.
^ Rabin M, McClelland A, Kühn L, Ruddle FH (1985). „Regional localization of the human transferrin receptor gene to 3q26.2----qter”. Am. J. Hum. Genet. 37 (6): 1112—6. PMC 1684729 . PMID 3002171.
^ Aisen P (2004). „Transferrin receptor 1”. Int. J. Biochem. Cell Biol. 36 (11): 2137—43. PMID 15313461. doi:10.1016/j.biocel.2004.02.007.
^ Moos T (2002). „Brain iron homeostasis”. Danish Medical Bulletin. 49 (4): 279—301. PMID 12553165.

[pmid6270680-1] Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (1981). „Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin”. Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515—9. PMC 319822 . PMID 6270680. doi:10.1073/pnas.78.7.4515.

[pmid3002171-2] Rabin M, McClelland A, Kühn L, Ruddle FH (1985). „Regional localization of the human transferrin receptor gene to 3q26.2----qter”. Am. J. Hum. Genet. 37 (6): 1112—6. PMC 1684729 . PMID 3002171.

[pmid15313461-3] Aisen P (2004). „Transferrin receptor 1”. Int. J. Biochem. Cell Biol. 36 (11): 2137—43. PMID 15313461. doi:10.1016/j.biocel.2004.02.007.

[pmid12553165-4] Moos T (2002). „Brain iron homeostasis”. Danish Medical Bulletin. 49 (4): 279—301. PMID 12553165.

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